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It is homologous to ALD-52, which contains an acetyl group instead of the propionyl group bound to the same location.Lysergic acid diethylamide (also known as Lysergide, LSD-25, LSD, L, Lucy, and Acid) is a classical psychedelic substance of the lysergamide class.[2] It is perhaps the most researched and culturally influential psychedelic substance, as well as the prototypal lysergamide. The mechanism of action is not fully known, although serotonin binding activity is thought to be involved. Key Points. Question Did trends in the prevalence of past-year lysergic acid diethylamide (LSD) use differ between adults with and adults without depression between 2008 and 2019?. 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