Guide for the care and use of laboratory animals - Jul 8, 2019 ... Guidelines · 1. Respect for animals' dignity · 2. Responsibility for considering options (Replace) · 3. The principle of proportionality:&n...

 
Occupational Health and Safety in the Care and Use of Research Animals (1997) Guide for the Care and Use of Laboratory Animals (1996) Rodents (1996) Nutrient Requirements of Laboratory Animals, Fourth Revised Edition (1995) Laboratory Animal Management: Dogs (1994) Recognition and Alleviation of Pain and Distress in Laboratory Animals (1992) . Sam cooke bring it on home to me

Chicago. Committee for the Update of the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal Research, Division on Earth and Life Studies, and National Research Council. 2010. Guide for the Care and Use of Laboratory Animals. 8th ed. Washington, D.C., DC: National Academies Press. Copy citation.The way an animal takes care of its young is determined by the type and species of the animal. All birds lay eggs that they must protect and incubate, although this is accomplished...The Guide for the Care and Use of Laboratory Animals, first published by the National Academy of Sciences in 1963 and revised since then, provides benchmark ...A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including …Define an outcome but do not limit the methods used to achieve the outcome. Defines both the outcome and the methodology used to achieve the outcome. Does not penetrate or expose a body cavity and causes little or no physical impairment. Study with Quizlet and memorize flashcards terms like Performance Standard, Engineering Standard, Must and more. The living conditions of animals should be appropriate for their species and contribute to their health and comfort. Normally, the housing, feeding, and care of all animals used for biomedical purposes must be directed by a veterinarian or other scientist trained and experienced in the proper care, handling, and use of the species being maintained or …Veterinary professionals working in partnership with other competent persons are essential for a successful animal care and use programme. A veterinarian's primary responsibilities are defined by their own professional regulatory bodies, but in this area of work there are further opportunities for contribution, which will assist in safeguarding the …We’re fortunate to live in a world where we can have practically anything we need brought right to our homes, ranging from groceries to a new car. Thankfully, many pet companies ha...The Guide for the Care and Use of Laboratory Animals was released to the sponsors and the public on January 2, 1996, in a prepublication form. After that, the Institute of Laboratory Animal Resources (ILAR) received comments from users and members of the Committee to Revise the Guide. The Guide has always been characterized as a living document, subject to modification with changing conditions ... The Guide for the Care and Use of Laboratory Animals (the Guide) was first published in 1963 under the title Guide for Laboratory Animal Facilities and Care and was revised in 1965, 1968, 1972, 1978, 1985, and 1996. More than 550,000 copies have been printed since its first publication. The Guide is an internationally accepted Guide Guide The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities—a resource of proven value, now updated and expanded. This revision will be important to researchers, animal care technicians, facilities managers, administrators at research institutions, policymakers ... The proper care and use of laboratory animals in research, testing, teaching, and production (animal use) require scientific and professional judgment based on the …*For guidance throughout these Principles, the reader is referred to the Guide for the Care and Use of Laboratory Animals prepared by the Institute of Laboratory Animal Resources, National Academy of Sciences. * * Published in the Federal Register, May 20, 1985, Vol. 50, No. 97, by the Office of Science and Technology Policy …Appendices. Appendix A Additional Selected References. Appendix B U.S. Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training. Appendix C Statement of Task. Appendix D About the Authors. Jun 16, 2022 ... This video explains the working and requirement of animal house facilities as per the CPCSEA guidelines. This material is taken from the ...Guide for the Care and Use of Laboratory Animals (8th edn) Udo Albus [email protected] View all authors and affiliations. ... Guidelines for the veterinary care of laboratory animals: Report of the FELASA/ECLAM/ESLAV Joint Working Group on Veterinary Care. Show details Hide details.Sec. 495. (a) The Secretary, acting through the Director of NIH, shall establish guidelines for the following: " (1) The proper care of animals to be used in biomedical and behavioral research. " (2) The proper treatment of animals while being used in such research. Guidelines under this paragraph shall require-.The PHS Policy relies on the Guide for the Care and Use of Laboratory Animals ("The Guide"), a set of research animal care standards first issued in 1963. The PHS Policy requires institutions to use this guide as a basis for developing and implementing institutional programs for research involving animals. The PHS Policy has been modified …A comprehensive resource for animal care and use, based on input from experts and the public. The Guide covers major components of animal use, such as institutional …The PHS Policy relies on the Guide for the Care and Use of Laboratory Animals ("The Guide"), a set of research animal care standards first issued in 1963. The PHS Policy requires institutions to use this guide as a basis for developing and implementing institutional programs for research involving animals. The PHS Policy has been modified …The Guide, published by the National Research Council and the Institute for Laboratory Animal Research, is not only the basis for AAALAC International accreditation (mentioned previously) but is also a central part of Public Health Service Policy on the humane care and use of laboratory animals. The Guide's recommendations are enforceable based ...1. Key Concepts. This edition of the Guide for the Care and Use of Laboratory Animals (the Guide) strongly affirms the principle that all who care for, use, or produce animals for research, testing, or teaching must assume responsibility for their well-being. The Guide is created by scientists and veterinarians for scientists and veterinarians ... Guide is subject to modification with changing conditions and new information. The purpose of the Guide, as expressed in the charge to the Committee to Revise the Guide for the Care and Use of Laboratory Animals, is to assist institutions in caring for and using animals in ways judged to be scientifically, technically, and humanely appropriate.Learn about the policies, regulations, and guidance that protect animals used in research, training, and testing. The Public Health Service Policy on Humane Care and Use of Laboratory Animals (PHS Policy) applies to activities supported by any PHS agency. The PHS Policy incorporates the U.S. Government Principles, the Guide, and …Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research ...The Committee on Educational Programs in Laboratory Animal Science was appointed in 1988 to "prepare an annotated syllabus [guide] for a course in humane practices of animal care and use to assist institutions in complying with recently enacted federal laws, which mandate that educational programs be provided for personnel who use animals in …The Guide for the Care and Use of Laboratory Animals ... When I looked through the [1996] US Guide for the Care and Use of Laboratory Animals, distress was mentioned only in conjunction with pain (i.e., “pain and distress”); there was no separate guidance on distress. But hopefully the ILAR report on distress will change that. I received only three …Chemical laboratories play a crucial role in various industries, including pharmaceuticals, agriculture, and manufacturing. These labs are responsible for conducting tests, analyzi...This chapter provides guidelines for the environment, housing, and management of laboratory animals used or produced for research, testing, and teaching. These guidelines are applicable across species and are relatively general; additional information should be sought about how to apply them to meet the specific needs of any species, strain, or use (see Appendix A for references). The chapter ... As a laboratory animal professional he has designed and overseen the construction of five animal facilities for research animals and a zoological park. Dr. Quimby has had broad experience with a wide assortment of laboratory animals including rodents, dogs, primates, livestock, poultry, and fish, and published on the diseases, care, and /or ...The care and use of laboratory animals impose responsibilities on various professionals with different backgrounds. Frequently, there is overlap in the functions and responsibilities of these different professionals. ... Diehl K-H, Hull R, Morton D, Pfister R., et al. (2001) A good practice guide to the administration of substances and removal of …Criteria and process for getting an Animal Welfare Assurance. A federal interagency project to empower IACUCs and institutions to increase compliance while minimizing burden. How to report situations of noncompliance and animal welfare concerns. Learn about the PHS Policy on Humane Care and Use of Laboratory Animals through …A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been revised by a committee of experts, based on input from scientists and the public. The incorporates recent research on commonly used species, including farm animals, and includes extensive references. It is organized around major components of …The use of laboratory animals for biomedical research, testing and education is guided by the principles of the Three Rs, replacement of animals where acceptable non-animal models exist, reduction in the number of animals to the fewest needed to obtain statistically significant data, and refinement of animal care and use to minimize pain and distress and to enhance animal well-being. This chapter provides guidelines for the environment, housing, and management of laboratory animals used or produced for research, testing, and teaching. These guidelines are applicable across species and are relatively general; additional information should be sought about how to apply them to meet the specific needs of any species, strain, or use (see Appendix A for references). The chapter ... GUIDE LABORATORY ANIMALS FOR THE CARE AND USE OF Eighth Edition Committee for the Update of the Guide for the Care . and Use of Laboratory Animals Institute for Laboratory Animal Research. Division on Earth and Life Studies. THE NATIONAL ACADEMIES PRESS 500 Fifth Street, NW Washington, DC 20001.The Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals requires that Assured institutions base their animal care and use programs on the Guide for the Care and Use of Laboratory Animals (Guide).The Office of Laboratory Animal Welfare (OLAW) is the National Institutes of Health (NIH) office responsible for the …Education and Training in the Care and Use of Laboratory Animals: A Guide for Developing Institutional Programs. 1991. National Research Council. Washington: National Academy Press. FELASA recommendations for the accreditation of laboratory animal science education and training. 2002. The living conditions of animals should be appropriate for their species and contribute to their health and comfort. Normally, the housing, feeding, and care of all animals used for biomedical purposes must be directed by a veterinarian or other scientist trained and experienced in the proper care, handling, and use of the species being maintained or …This unit provides a general overview on topics related to the practical care and use of laboratory animals in biomedical research. These topics are briefly described and provide Web sites and/or research articles that can be accessed for more detailed information. While the primary focus is on the …Nelson L. Garnett, Laboratory Animal Care and Use Programs, Dickerson, MD Estelle B. Gauda, Johns Hopkins University School of Medicine, Johns ... Education and Training in the Care and Use of Laboratory Animals: A Guide for Developing Institutional Programs (1991) Companion Guide to Infectious Diseases of Mice and Rats (1991) ...This tutorial is for new animal care and use committee members, institutional administrators, investigators, animal care personnel, veterinarians, and others who are interested in learning about the Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals ( Policy ). Introduction. Health Research Extension Act of …The Care and Use of Amphibians, Reptiles, and Fish in Research; Proceedings from a SCAW/LSU-SVM-sponsored conference; April 8–9, 1991; New Orleans. Greenbelt MD: Scientists Center for Animal Welfare; 1992. Ostrander GK, Bullock GR, Bunton T, editors. The Handbook of Experimental Animals: The Laboratory Fish. Academic Press; 2000. Cheetahs are very good mothers, caring for their young until the cubs reach maturity, usually between ages 2 and 3. Cheetahs are ordinarily solitary animals, preferring to venture ...The . National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the fuThis unit provides a general overview on topics related to the practical care and use of laboratory animals in biomedical research. These topics are briefly described and provide Web sites and/or research articles that can be accessed for more detailed information. While the primary focus is on the …Criteria and process for getting an Animal Welfare Assurance. A federal interagency project to empower IACUCs and institutions to increase compliance while minimizing burden. How to report situations of noncompliance and animal welfare concerns. Learn about the PHS Policy on Humane Care and Use of Laboratory Animals through …For example, the emphasis of the 1996 edition of the Guide for the Care and Use of Laboratory Animals on performance goals as opposed to engineering approaches is a theme that resonates throughout. Other new reports, such as the 1997 Occupational Health and Safety in the Care and Use of Research Animals and the 1998 The Psychological …Guide for the Care and Use of Laboratory Animals Issue 86, Part 23 of NIH publication: Contributor: Institute of Laboratory Animal Resources (U.S.). Committee on Care and Use of Laboratory Animals: Edition: revised: Publisher: U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, 1986: Original fromThe Guide for Laboratory Animal Facilities and Care, published by the ACP in 1963, was first revised in 1965 and renamed the Guide for the Care and Use of Laboratory Animals (NRC Guide). The 1965 revision, and subsequent editions, was published by the Institute for Laboratory Animal Resources (ILAR) (now known as the Institute for Laboratory …The Guide for the Care and Use of Laboratory Animals, ILAR Journal, Volume 56, Issue 1, 19 May 2015, Pages NP, https://doi.org/10.1093/ilar/ilv024The IACUC is responsible for oversight of the animal care and use program and its components as described in the Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals ( Policy) and the Guide for the Care and Use of Laboratory Animals ( Guide). Its oversight functions include an ongoing assessment of …Proper housing and management of animal facilities are essential to animal well-being, to the quality of research data and teaching or testing programs in which animals are used, and to the health and safety of personnel. A good management program provides the environment, housing, and care that permit animals to grow, mature, reproduce, and maintain good health; provides for their well-being ... The Guide for the Care and Use of Laboratory Animals (the Guide) was first published in 1963 under the title Guide for Laboratory Animal Facilities and Care and was revised in 1965, 1968, 1972, 1978, and 1985. More than 400,000 copies have been distributed since it was first published, and it is widely accepted as a primary reference on animal care and …This report is the Tamil translation of Guide for the Care and Use of Laboratory Animals: Eighth Edition.. A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The …A committee of experts has updated the 1996 version of the Guide for the Care and Use of Laboratory Animals, taking into consideration input from the scientific and …Read Free Online. Buy Paperback: $47.00. A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been revised by a committee of experts, based on input from scientists and the public. The Guide incorporates recent research on commonly used species, including farm animals, and includes extensive references.The Guide for the Care and Use of Laboratory Animals, ILAR Journal, Volume 57, Issue 2, 1 December 2016, Pages NP, https://doi.org/10.1093/ilar/ilw049ILAR assists institutions in using and caring for animals in ways that are scientifically, technically, and humanely appropriate. This standing committee was established to inform future revisions to the Guide for the Care and Use of Laboratory Animals, which serves as the basis for accreditation for animal research worldwide. ... guidelines contained in the Guide for the Care and Use of Laboratory Animals and applicable provisions of the Animal Welfare Act. Veterinary care including ...This report is the Thai translation of Guide for the Care and Use of Laboratory Animals: Eighth Edition.. A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The …Proper housing and management of animal facilities are essential to animal well-being, to the quality of research data and teaching or testing programs in which animals are used, and to the health and safety of personnel. A good management program provides the environment, housing, and care that permit animals to grow, mature, reproduce, and maintain good health; provides for their well-being ... GUIDE LABORATORY ANIMALS FOR THE CARE AND USE OF Eighth Edition Committee for the Update of the Guide for the Care . and Use of Laboratory Animals Institute for Laboratory Animal Research. Division on Earth and Life Studies. THE NATIONAL ACADEMIES PRESS 500 Fifth Street, NW Washington, DC 20001. NOTICE: …tion—continue to be the core foundation of the Guide for scientifi c laboratory animal use. Th e three Rs are a practical strategy for researchers to apply when consider-ing experiments that involve the use of laboratory animals and in designing humane animal research studies. 2. A framework for an Animal Care and Use Program is Occupational Health and Safety in the Care and Use of Research Animals (1997) Guide for the Care and Use of Laboratory Animals (1996) Rodents (1996) Nutrient Requirements of Laboratory Animals, Fourth Revised Edition (1995) Laboratory Animal Management: Dogs (1994) Recognition and Alleviation of Pain and Distress in Laboratory Animals (1992) Subsequent editions of the Guide were supported by NIH and published by the Institute of Laboratory Animal Research branch of the National Academy of Science.Project details · Upcoming Conferences: · New and Noteworthy: · Leave a Reply Cancel Reply. Your email address will not be published.Jan 27, 2011 · The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers ... Guide for the Care and Use of Laboratory Animals: Eighth Edition The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare.GUIDE LABORATORY ANIMALS FOR THE CARE AND USE OF Eighth Edition Committee for the Update of the Guide for the Care . and Use of Laboratory Animals …Public Health Service Policy on Humane Care and Use of Laboratory Animals I. Introduction. It is the Policy of the Public Health Service (PHS) to require institutions to establish and maintain proper measures to ensure the appropriate care and use of all animals involved in research, research training, and biological testing activities (hereinafter referred to as "activities") conducted or ... Sep 2, 2022 ... KEY POINTS · Animals used for experimental purposes must receive appropriate care and treatment. · Establishments should ensure the following.The Guide underwent its seventh revision and the eighth edition was published in 2011. Its purpose is to assist scientific institutions in caring for and using animals in ways judged to be scientifically, technically and humanely appropriate. It is a long-standing NIH policy that grantees and contractors using live vertebrate animals in ... The use of laboratory animals for biomedical research, testing and education is guided by the principles of the Three Rs, replacement of animals where acceptable non-animal models exist, reduction in the number of animals to the fewest needed to obtain statistically significant data, and refinement of animal care and use to minimize pain and distress and to enhance animal well-being. The Guide ... Veterinary care is an essential part of an animal care and use Program. The primary focus of the veterinarian is to oversee the well-being and clinical care of animals used in research, testing, teaching, and production. This responsibility extends to monitoring and promoting animal well-being at all times during animal use and during all phases of the …The PHS Policy requires awardee institutions to use the Guide for the Care and Use of Laboratory Animals (NRC, 2011; Guide), as a basis for managing their animal care and use programs. The Guide provides a detailed set of performance standards encompassing major topics such as Institutional Animal Care and Use Committee (IACUC) structure …Aug 17, 2018 ... JoVE's animal research training videos save time and money for laboratories worldwide - increasing the safety of lab members and of the ...Nov 10, 2020 ... Research Involving Animals: NIH Office of Laboratory Animal Welfare (OLAW) · NIH Grants · Laws and Regulations Governing the Care and Use of ...The Guide for the Care and Use of Laboratory Animals (the Guide) was first published in 1963 under the title Guide for Laboratory Animal Facilities and Care and was revised in 1965, 1968, 1972, 1978, and 1985. More than 400,000 copies have been distributed since it was first published, and it is widely accepted as a primary reference on animal care and use. The changes and new material in this ... A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been revised by a committee of experts, based on input from scientists and the public. The incorporates recent research on commonly used species, including farm animals, and includes extensive references. It is organized around major components of …Chicago. Committee for the Update of the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal Research, Division on Earth and Life Studies, and National Research Council. 2010. Guide for the Care and Use of Laboratory Animals. 8th ed. Washington, D.C., DC: National Academies Press. Copy citation.

The PHS Policy requires institutions to use the Guide for the Care and Use of Laboratory Animals to develop and implement an institutional animal care and use program. Analgesics and other techniques should be used to minimize discomfort and pain except when the intervention would compromise experimental goals.. Dillon danis logan paul

guide for the care and use of laboratory animals

Apr 9, 2021 ... CPCSEA guidelines Subscribe to our channel for more updates https://www.youtube.com/channel/UCT6grIGsfukdC__QVE5EwdA.Jan 27, 2011 · The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers ... The Guide addresses pain recognition and relief and issues surrounding euthanasia. Physical plant. The committee identifies design and construction issues, providing guidelines for animal-room doors, drainage, noise control, surgery, and other areas. Read chapter 4 Physical Plant: A respected resource for decades, the Guide for the Care and …The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers …The Guide for the Care and Use of Laboratory Animals (the Guide), now in its eighth edition (2011), provides a framework for assisting “institutions in caring for animals in ways judged to be scientifically, technically, and humanely appropriate” and to “assist investigators in fulfilling their obligation to plan and conduct animal ...1.2 Applicable guidelines and principles including: 1) Guide for the Care and Use of Laboratory Animals, Institute of Laboratory Animal Resources, National Research Council, USA; 2) PALAS Code of Practice for the Care and Use of Laboratory Animals in the Philippines, and 3) The International Guiding Principles forAnimal research is tightly regulated via numerous laws, regulations, policies, guidelines, and agencies [ 3, 4, 12, 13 ]. Rather than dictating how research should be conducted, the intent of the regulations is twofold: (1) minimize the use of animals in research and (2) enhance the quality of life of research animals.This report is the Tamil translation of Guide for the Care and Use of Laboratory Animals: Eighth Edition.. A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The …The PHS Policy requires awardee institutions to use the Guide for the Care and Use of Laboratory Animals (NRC, 2011; Guide), as a basis for managing their animal care and use programs. The Guide provides a detailed set of performance standards encompassing major topics such as Institutional Animal Care and Use Committee (IACUC) structure and ... Guide for the Care and Use of Laboratory Animals -- Chinese Version. (2015) Read Free Online. Buy Paperback: $47.00. Contributor (s): National Research Council; Division on Earth and Life Studies; Commission on Life Sciences; Institute for Laboratory Animal Research. Login or Register for a free MyNAP member account to save 10% off online …The Guide for the Care and Use of Laboratory Animals was released to the sponsors and the public on January 2, 1996, in a prepublication form. After that, the Institute of Laboratory Animal Resources (ILAR) received comments from users and members of the Committee to Revise the Guide. The Guide has always been characterized as a living document, subject to modification with changing conditions ... Education and Training in the Care and Use of Laboratory Animals: A Guide for Developing Institutional Programs. 1991. National Research Council. Washington: National Academy Press. FELASA recommendations for the accreditation of laboratory animal science education and training. 2002. Jan 27, 2011 · The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers ... The PHS Policy on Humane Care and Use of Laboratory Animals is a document that outlines the ethical and legal standards for conducting research involving animals in PHS-funded institutions. It covers topics such as animal welfare assurance, institutional responsibilities, animal care and use committees, and reporting requirements. The …This chapter provides guidelines for the environment, housing, and management of laboratory animals used or produced for research, testing, and teaching. These guidelines are applicable across species and are relatively general; additional information should be sought about how to apply them to meet the specific needs of any species, strain, or use (see Appendix A for references). The chapter ... The Guide for the Care and Use of Laboratory Animals ... When I looked through the [1996] US Guide for the Care and Use of Laboratory Animals, distress was mentioned only in conjunction with pain (i.e., “pain and distress”); there was no separate guidance on distress. But hopefully the ILAR report on distress will change that. I received only three …The Committee on Educational Programs in Laboratory Animal Science was appointed in 1988 to "prepare an annotated syllabus [guide] for a course in humane practices of animal care and use to assist institutions in complying with recently enacted federal laws, which mandate that educational programs be provided for personnel who use animals in …A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been revised by a committee of experts, based on input from scientists and the public. The Guide incorporates recent research on commonly used species, including farm animals, and includes extensive references. It is organized around major components of animal use: Institutional policies and ... May 19, 2015 · The Guide for the Care and Use of Laboratory Animals, ILAR Journal, Volume 56, Issue 1, 19 May 2015, Pages NP, https://doi.org/10.1093/ilar/ilv024 .

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